Version 5.4
Homo sapiens Protein: CXCL5
Summary
InnateDB Protein IDBP-24183.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL5
Protein Name chemokine (C-X-C motif) ligand 5
Synonyms ENA-78; SCYB5;
Species Homo sapiens
Ensembl Protein ENSP00000296027
InnateDB Gene IDBG-24181 (CXCL5)
Protein Structure
UniProt Annotation
Function Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. {ECO:0000269PubMed:10095777}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42830
PhosphoSite PhosphoSite-P42830
TrEMBL Q6I9S7
UniProt Splice Variant
Entrez Gene 6374
UniGene Hs.89714
RefSeq NP_002985
HUGO HGNC:10642
OMIM 600324
CCDS CCDS34006
HPRD 08976
IMGT
EMBL AC097709 AF349466 AJ315732 AK312128 BC008376 BT006807 CH471057 CR457428 L37036 U12709 X78686
GenPept AAA62475 AAA86426 AAH08376 AAK29641 AAP35453 AAY41005 BAG35064 CAA55355 CAC42884 CAG33709 EAX05696

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca