InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCL25

Summary

InnateDB Gene

IDBG-24184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL25

Gene Name

chemokine (C-C motif) ligand 25

Synonyms

Ckb15; SCYA25; TECK

Species

Homo sapiens

Ensembl Gene

ENSG00000131142

Encoded Proteins

IDBP-24186

chemokine (C-C motif) ligand 25

IDBP-24188

chemokine (C-C motif) ligand 25

IDBP-24190

chemokine (C-C motif) ligand 25

IDBP-369067

chemokine (C-C motif) ligand 25

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:8052767-8062650

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000390669	ENSP00000375086
ENST00000253451	ENSP00000253451
ENST00000315626	ENSP00000324756
ENST00000458625	ENSP00000401882

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008009	chemokine activity
GO:0031735	CCR10 chemokine receptor binding
GO:0042379	chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050900	leukocyte migration
GO:0060326	cell chemotaxis