InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCL25

Summary

InnateDB Protein

IDBP-24188.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL25

Protein Name

chemokine (C-C motif) ligand 25

Synonyms

Ckb15; SCYA25; TECK;

Species

Homo sapiens

Ensembl Protein

ENSP00000253451

InnateDB Gene

IDBG-24184 (CCL25)

Protein Structure

UniProt Annotation

Function

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0008009	chemokine activity
GO:0031735	CCR10 chemokine receptor binding
GO:0042379	chemokine receptor binding

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0060326	cell chemotaxis