Homo sapiens Gene: CXCL3
Summary
InnateDB Gene IDBG-24221.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL3
Gene Name chemokine (C-X-C motif) ligand 3
Synonyms CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3;
Species Homo sapiens
Ensembl Gene ENSG00000163734
Encoded Proteins
chemokine (C-X-C motif) ligand 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cxcl2 is a chemokine secreted by kidney dendritic cells to recruit neutrophils to sites of uropathogenic bacterial infection.
[Mus musculus] Cebpa suppresses granule formation in mast cells and increases Cxcl2 production from mast cells upon bacterial stimulation.
Entrez Gene
Summary This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74036589-74038807
Strand Reverse strand
Band q13.3
Transcripts
ENST00000296026 ENSP00000296026
ENST00000511669
ENST00000502974
ENST00000510390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0030593 neutrophil chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.617230 Hs.89690
RefSeq NM_002090
HUGO
OMIM
CCDS CCDS34007
HPRD 00742
IMGT
EMBL
GenPept
RNA Seq Atlas