Version 5.4
Homo sapiens Protein: CXCL3
Summary
InnateDB Protein IDBP-24223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL3
Protein Name chemokine (C-X-C motif) ligand 3
Synonyms CINC-2b; GRO3; GROg; MIP-2b; MIP2B; SCYB3;
Species Homo sapiens
Ensembl Protein ENSP00000296026
InnateDB Gene IDBG-24221 (CXCL3)
Protein Structure
UniProt Annotation
Function Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. {ECO:0000250, ECO:0000269PubMed:10095777}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0030593 neutrophil chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19876
PhosphoSite PhosphoSite-
TrEMBL Q6LD32
UniProt Splice Variant
Entrez Gene 2921
UniGene Hs.89690
RefSeq NP_002081
HUGO HGNC:4604
OMIM 139111
CCDS CCDS34007
HPRD 00742
IMGT
EMBL AC097709 BC016308 BC065743 CH471057 M36821 U03020 X53800
GenPept AAA03454 AAA63184 AAH16308 AAH65743 AAY41006 CAA37809 EAX05698

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca