Homo sapiens Gene: CXCL2
Summary
InnateDB Gene IDBG-24257.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL2
Gene Name chemokine (C-X-C motif) ligand 2
Synonyms CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2; MIP2A; SCYB2;
Species Homo sapiens
Ensembl Gene ENSG00000081041
Encoded Proteins
chemokine (C-X-C motif) ligand 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CXCL2 is a chemokine secreted by kidney dendritic cells to recruit neutrophils to sites of uropathogenic bacterial infection. (Demonstrated in mouse)
Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
Entrez Gene
Summary This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74097035-74099293
Strand Reverse strand
Band q13.3
Transcripts
ENST00000296031
ENST00000508487 ENSP00000427279
ENST00000510048
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008009 chemokine activity
Biological Process
GO:0002237 response to molecule of bacterial origin
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0045087 innate immune response (InnateDB)
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
NOD-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P19875
TrEMBL A0A024RDD9 Q6LD33
UniProt Splice Variant
Entrez Gene 2920
UniGene Hs.75765
RefSeq NM_002089
HUGO HGNC:4603
OMIM 139110
CCDS CCDS34008
HPRD
IMGT
EMBL AF043340 BC015753 CH471057 CR542171 M36820 M57731 U03019 X53799
GenPept AAA03453 AAA63182 AAA63183 AAC03540 AAH15753 CAA37808 CAG46968 EAX05700 EAX05701
RNA Seq Atlas 2920