|Homo sapiens Gene: CXCL2|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||chemokine (C-X-C motif) ligand 2|
|Synonyms||CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2; MIP2A; SCYB2|
chemokine (C-X-C motif) ligand 2
|Useful resources||Stemformatics EHFPI ImmGen|
CXCL2 is a chemokine secreted by kidney dendritic cells to recruit neutrophils to sites of uropathogenic bacterial infection. (Demonstrated in mouse)
Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.
|InnateDB Annotation from Orthologs|
[Mus musculus] Defb1 is important for the control of early mucosal Candida infection and plays a critical role in the induction of innate inflammatory mediators including, Il1b, Il6, Cxcl1, Il17a, and Il17f.
This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
|Genomic Location||Chromosome 4:74097035-74099293|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
NOD-like receptor signaling pathway pathway
|UniProt Splice Variant|
|EMBL||AF043340 BC015753 CH471057 CR542171 M36820 M57731 U03019 X53799|
|GenPept||AAA03453 AAA63182 AAA63183 AAC03540 AAH15753 CAA37808 CAG46968 EAX05700 EAX05701|
|RNA Seq Atlas||2920|