InnateDB Protein
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IDBP-478241.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CXCL2
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Protein Name
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chemokine (C-X-C motif) ligand 2
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Synonyms
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CINC-2a; GRO2; GROb; MGSA-b; MIP-2a; MIP2; MIP2A; SCYB2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000427279
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InnateDB Gene
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IDBG-24257 (CXCL2)
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Protein Structure
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Function |
Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. {ECO:0000269PubMed:10725737}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
|
Protein-Protein |
11
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001089
CXC chemokine
IPR001811
Chemokine interleukin-8-like domain
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PFAM |
PF00048
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PRINTS |
PR00437
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PIRSF |
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SMART |
SM00199
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TIGRFAMs |
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Modification |
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SwissProt |
P19875
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q6LD33
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UniProt Splice Variant |
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Entrez Gene |
2920
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UniGene |
Hs.75765
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RefSeq |
NP_002080
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HUGO |
HGNC:4603
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OMIM |
139110
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CCDS |
CCDS34008
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HPRD |
00741
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IMGT |
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EMBL |
AF043340
BC015753
CH471057
CR542171
M36820
M57731
U03019
X53799
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GenPept |
AAA03453
AAA63182
AAA63183
AAC03540
AAH15753
CAA37808
CAG46968
EAX05700
EAX05701
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