Homo sapiens Gene: NRAS
Summary
InnateDB Gene IDBG-243969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NRAS
Gene Name neuroblastoma RAS viral (v-ras) oncogene homolog
Synonyms ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6;
Species Homo sapiens
Ensembl Gene ENSG00000213281
Encoded Proteins
neuroblastoma RAS viral (v-ras) oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NRAS is a small GTPase that, in response to microbial activation, mediates cholangiocyte pro-inflammatory cytokine production and induction of cholangiocyte proliferation.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nras is a small GTPase that, in response to microbial activation, mediates cholangiocyte pro-inflammatory cytokine production and induction of cholangiocyte proliferation. (Demonstrated in human)
Entrez Gene
Summary This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:114704469-114716894
Strand Reverse strand
Band p13.2
Transcripts
ENST00000369535 ENSP00000358548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 29 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0032403 protein complex binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008542 visual learning
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0015031 protein transport
GO:0030036 actin cytoskeleton organization
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0035022 positive regulation of Rac protein signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045596 negative regulation of cell differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0050900 leukocyte migration
GO:0051146 striated muscle cell differentiation
GO:0060441 epithelial tube branching involved in lung morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signalling to p38 via RIT and RIN pathway
FRS2-mediated cascade pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SOS-mediated signalling pathway
Activation of RAS in B cells pathway
p38MAPK events pathway
SHC1 events in ERBB4 signaling pathway
DAP12 signaling pathway
NCAM signaling for neurite out-growth pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
Signaling by constitutively active EGFR pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
RAF activation pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
SHC-related events triggered by IGF1R pathway
Signaling by SCF-KIT pathway
Frs2-mediated activation pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
IRS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
Adaptive Immune System pathway
SHC-mediated signalling pathway
Immune System pathway
Downstream signal transduction pathway
GRB2 events in EGFR signaling pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Interleukin-2 signaling pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
IRS-related events pathway
SHC1 events in ERBB2 signaling pathway
IGF1R signaling cascade pathway
ARMS-mediated activation pathway
EGFR Transactivation by Gastrin pathway
Prolonged ERK activation events pathway
Signaling by FGFR pathway
Signalling to RAS pathway
Signaling by PDGF pathway
MEK activation pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Cell surface interactions at the vascular wall pathway
Disease pathway
RAF phosphorylates MEK pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Axon guidance pathway
VEGF signaling pathway pathway
Tight junction pathway
Gap junction pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Long-term potentiation pathway
Neurotrophin signaling pathway pathway
Long-term depression pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
GnRH signaling pathway pathway
Melanogenesis pathway
Hepatitis C pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Endometrial cancer pathway
Glioma pathway
Prostate cancer pathway
Thyroid cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IGF1 signaling pathway pathway
NGF signaling pathway pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
PID BIOCARTA
PID NCI
C-MYB transcription factor network
Regulation of Ras family activation
Cross-References
SwissProt P01111
TrEMBL P78460 Q5U091 Q71SP6 Q9UM97
UniProt Splice Variant
Entrez Gene 4893
UniGene Hs.486502 Hs.615805 Hs.732828
RefSeq NM_002524
HUGO HGNC:7989
OMIM 164790
CCDS CCDS877
HPRD
IMGT
EMBL AF285779 AF493919 AY428630 BC005219 BT019734 BT019735 CH471122 EF685661 EF685662 EU332857 JQ248012 K03211 L00040 L00041 L00042 L00043 M10055 M19990 M25898 S68580 X00642 X00643 X00644 X00645 X02751 X05565 X07440 X53291 X53292
GenPept AAA36548 AAA36556 AAA52693 AAA60255 AAB29639 AAF91482 AAH05219 AAM12633 AAQ94397 AAV38539 AAV38540 ABS10683 ABS10684 ABY87546 AFF18187 CAA25269 CAA25270 CAA25271 CAA25272 CAA26529 CAA29079 CAA30320 CAA37384 EAW56608 EAW56609 EAW56610 EAW56611
RNA Seq Atlas 4893