Homo sapiens Gene: CCNA1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-24529.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CCNA1 | ||||||||||||||||||||||
Gene Name | cyclin A1 | ||||||||||||||||||||||
Synonyms | CT146 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000133101 | ||||||||||||||||||||||
Encoded Proteins |
cyclin A1
cyclin A1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 13:36431830-36442882 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q13.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Regulation of APC/C activators between G1/S and early anaphase pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Cyclin E associated events during G1/S transition pathway
E2F mediated regulation of DNA replication pathway
G2 Phase pathway
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway
Cyclin A/B1 associated events during G2/M transition pathway
DNA Replication pathway
Cellular responses to stress pathway
Synthesis of DNA pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Mitotic G2-G2/M phases pathway
Regulation of DNA replication pathway
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KEGG |
Acute myeloid leukemia pathway
Cell cycle pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
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INOH | |||||||||||||||||||||||
PID NCI |
C-MYB transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | P78396 | ||||||||||||||||||||||
TrEMBL | F6KX25 Q9UNG8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8900 | ||||||||||||||||||||||
UniGene | Hs.417050 Hs.628987 | ||||||||||||||||||||||
RefSeq | NM_001111045 NM_001111046 NM_001111047 NM_003914 | ||||||||||||||||||||||
HUGO | HGNC:1577 | ||||||||||||||||||||||
OMIM | 604036 | ||||||||||||||||||||||
CCDS | CCDS45031 CCDS9357 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF124143 AK301897 AK316392 AL359767 BC036346 BT019577 CH471075 HQ662956 U66838 U97680 | ||||||||||||||||||||||
GenPept | AAB49754 AAB60863 AAD26337 AAH36346 AAV38384 AEF32519 BAH13579 BAH14763 CAI12728 EAX08565 EAX08566 | ||||||||||||||||||||||
RNA Seq Atlas | 8900 | ||||||||||||||||||||||