InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNA1

Summary

InnateDB Protein

IDBP-365002.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNA1

Protein Name

cyclin A1

Synonyms

CT146;

Species

Homo sapiens

Ensembl Protein

ENSP00000400666

InnateDB Gene

IDBG-24529 (CCNA1)

Protein Structure

UniProt Annotation

Function

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. {ECO:0000269PubMed:10022926}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	71 [view]
Protein-Protein	70 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0051726	regulation of cell cycle