Homo sapiens Gene: RAB11B
Summary
InnateDB Gene IDBG-24714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB11B
Gene Name RAB11B, member RAS oncogene family
Synonyms H-YPT3;
Species Homo sapiens
Ensembl Gene ENSG00000185236
Encoded Proteins
RAB11B, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:8389981-8404434
Strand Forward strand
Band p13.2
Transcripts
ENST00000328024 ENSP00000333547
ENST00000598706
ENST00000600719 ENSP00000473042
ENST00000601897 ENSP00000472473
ENST00000594216 ENSP00000471148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0001881 receptor recycling
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0032402 melanosome transport
GO:0033572 transferrin transport
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0044070 regulation of anion transport
GO:0045054 constitutive secretory pathway
GO:0045055 regulated secretory pathway
GO:0071468 cellular response to acidity
GO:1990126 retrograde transport, endosome to plasma membrane
GO:2000008 regulation of protein localization to cell surface
GO:2001135 regulation of endocytic recycling
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0030670 phagocytic vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0045335 phagocytic vesicle
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
Vasopressin-regulated water reabsorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.626404
RefSeq NM_004218
HUGO
OMIM
CCDS CCDS12201
HPRD 05009
IMGT
EMBL
GenPept
RNA Seq Atlas