Version 5.4
Homo sapiens Gene: LRRFIP2
Summary
InnateDB Gene IDBG-24724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRFIP2
Gene Name leucine rich repeat (in FLII) interacting protein 2
Synonyms HUFI-2
Species Homo sapiens
Ensembl Gene ENSG00000093167
Encoded Proteins
IDBP-24726
leucine rich repeat (in FLII) interacting protein 2
IDBP-24728
leucine rich repeat (in FLII) interacting protein 2
IDBP-237523
leucine rich repeat (in FLII) interacting protein 2
IDBP-371170
leucine rich repeat (in FLII) interacting protein 2
IDBP-371174
leucine rich repeat (in FLII) interacting protein 2
IDBP-371176
leucine rich repeat (in FLII) interacting protein 2
IDBP-371185
leucine rich repeat (in FLII) interacting protein 2
IDBP-371194
leucine rich repeat (in FLII) interacting protein 2
IDBP-371199
leucine rich repeat (in FLII) interacting protein 2
IDBP-371201
leucine rich repeat (in FLII) interacting protein 2
IDBP-371203
leucine rich repeat (in FLII) interacting protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21220426
LRRFIP2, when phosphorylated at serine 202, interacts with MYD88 during LPS stimulation to induces NFKB activity.
InnateDB Annotation from Orthologs
Summary
PMID 21220426
[Mus musculus] Lrrfip2, upon phosphorylation, interacts with Myd88 during LPS stimulation and induces NFKB activity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:37052656-37183689
Strand Reverse strand
Band p22.2
Transcripts
ENST00000336686 ENSP00000338727
ENST00000354379 ENSP00000346349
ENST00000396428 ENSP00000379705
ENST00000421276 ENSP00000416364
ENST00000440230 ENSP00000405480
ENST00000440742 ENSP00000413026
ENST00000416425 ENSP00000409574
ENST00000438374 ENSP00000412206
ENST00000452742 ENSP00000391360
ENST00000436858 ENSP00000416013
ENST00000434749 ENSP00000416907
ENST00000460646
ENST00000496479
ENST00000487246
ENST00000481682
ENST00000461672
ENST00000482466
ENST00000490597
ENST00000496825
ENST00000483306
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030275 LRR domain binding
GO:0046983 protein dimerization activity
Biological Process
GO:0008150 biological_process
GO:0016055 Wnt signaling pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032497
View Gene Order
ENSBTAG00000016760
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.475319 Hs.740522
RefSeq NM_001134369 NM_001282691 NM_006309 NM_017724 XM_005265538 XM_005265539 XM_005265540 XM_006713385
HUGO
OMIM
CCDS CCDS2664 CCDS2665 CCDS46791 CCDS63592
HPRD 10061
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca