Version 5.4
Homo sapiens Gene: PRDM14
Summary
InnateDB Gene IDBG-24783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDM14
Gene Name PR domain containing 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147596
Encoded Proteins
IDBP-24785
PR domain containing 14
IDBP-372263
PR domain containing 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70051651-70071693
Strand Reverse strand
Band q13.3
Transcripts
ENST00000276594 ENSP00000276594
ENST00000426346 ENSP00000408653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001708 cell fate specification
GO:0001827 inner cell mass cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007281 germ cell development
GO:0009566 fertilization
GO:0010468 regulation of gene expression
GO:0030718 germ-line stem cell maintenance
GO:0032259 methylation
GO:0034972 histone H3-R26 methylation
GO:0040029 regulation of gene expression, epigenetic
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0044030 regulation of DNA methylation
GO:0048873 homeostasis of number of cells within a tissue
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042414
View Gene Order
ENSBTAG00000000060
Not yet available
Pathways
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.736037
RefSeq NM_024504
HUGO
OMIM
CCDS CCDS6206
HPRD 11457
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca