Version 5.4
| Homo sapiens Gene: DMTF1 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-24801.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | DMTF1 | ||||||||||||||||||||||
| Gene Name | cyclin D binding myb-like transcription factor 1 | ||||||||||||||||||||||
| Synonyms | DMP1; DMTF; hDMP1; MRUL | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Gene | ENSG00000135164 | ||||||||||||||||||||||
| Encoded Proteins |
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40%% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 7:87152361-87196337 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | q21.12 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME | |||||||||||||||||||||||
| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI |
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | C9J4F7 C9J8Y5 C9JED5 C9JFR2 C9JGT5 C9JLR5 C9JVQ7 C9JZZ6 C9K0K9 C9K0L9 F8VXY9 J3KRC1 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 9988 | ||||||||||||||||||||||
| UniGene | Hs.196129 | ||||||||||||||||||||||
| RefSeq | NM_001142326 NM_001142327 NM_021145 XM_005250734 XM_006716198 XM_006716199 XM_006716200 XM_006716201 XM_006716206 | ||||||||||||||||||||||
| HUGO | HGNC:14603 | ||||||||||||||||||||||
| OMIM | 608491 | ||||||||||||||||||||||
| CCDS | CCDS47633 CCDS5601 | ||||||||||||||||||||||
| HPRD | 09770 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AC005076 | ||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | 9988 | ||||||||||||||||||||||