Homo sapiens Gene: DMTF1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-24801.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | DMTF1 | ||||||||||||||||||||||
Gene Name | cyclin D binding myb-like transcription factor 1 | ||||||||||||||||||||||
Synonyms | DMP1; DMTF; hDMP1; MRUL | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000135164 | ||||||||||||||||||||||
Encoded Proteins |
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
cyclin D binding myb-like transcription factor 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40%% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:87152361-87196337 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q21.12 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | C9J4F7 C9J8Y5 C9JED5 C9JFR2 C9JGT5 C9JLR5 C9JVQ7 C9JZZ6 C9K0K9 C9K0L9 F8VXY9 J3KRC1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 9988 | ||||||||||||||||||||||
UniGene | Hs.196129 | ||||||||||||||||||||||
RefSeq | NM_001142326 NM_001142327 NM_021145 XM_005250734 XM_006716198 XM_006716199 XM_006716200 XM_006716201 XM_006716206 | ||||||||||||||||||||||
HUGO | HGNC:14603 | ||||||||||||||||||||||
OMIM | 608491 | ||||||||||||||||||||||
CCDS | CCDS47633 CCDS5601 | ||||||||||||||||||||||
HPRD | 09770 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC005076 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 9988 | ||||||||||||||||||||||