InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DMTF1

Summary

InnateDB Gene

IDBG-630810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMTF1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020878

Encoded Proteins

IDBP-682344

cyclin D binding myb-like transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135164:
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40%% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:33368816-33418724

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033813

ENSBTAP00000033722

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding

Biological Process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000135164

View Gene Order

ENSMUSG00000042508

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

ap1_pathway

AP-1 transcription factor network

Cross-References

SwissProt

TrEMBL

E1BQ00

UniProt Splice Variant

Entrez Gene

539676

UniGene

RefSeq

XM_002686719 XM_005198009 XM_005198010 XM_005198011 XM_005198012 XM_005198013 XM_005205307 XM_005205308 XM_005205309 XM_005205310 XM_005205311 XM_864821

HUGO

HGNC:14603

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02010257

GenPept

RNA Seq Atlas

539676