Homo sapiens Gene: ITGA9
Summary
InnateDB Gene IDBG-25124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA9
Gene Name integrin, alpha 9
Synonyms ALPHA-RLC; ITGA4L; RLC;
Species Homo sapiens
Ensembl Gene ENSG00000144668
Encoded Proteins
integrin, alpha 9
integrin, alpha 9
integrin, alpha 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:37452115-37823514
Strand Forward strand
Band p22.2
Transcripts
ENST00000264741 ENSP00000264741
ENST00000422441 ENSP00000397258
ENST00000411817 ENSP00000406533
ENST00000461533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0042060 wound healing
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0034679 alpha9-beta1 integrin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Extracellular matrix organization pathway
Axon guidance pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
L1CAM interactions pathway
Signal transduction by L1 pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Cell adhesion molecules (CAMs) pathway
Regulation of actin cytoskeleton pathway
Hypertrophic cardiomyopathy (HCM) pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Dilated cardiomyopathy pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Beta1 integrin cell surface interactions
Integrin family cell surface interactions
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.113157
RefSeq NM_002207
HUGO
OMIM
CCDS CCDS2669
HPRD 04910
IMGT
EMBL
GenPept
RNA Seq Atlas