Version 5.4
Homo sapiens Gene: ITGA9
Summary
InnateDB Gene IDBG-25124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA9
Gene Name integrin, alpha 9
Synonyms ALPHA-RLC; ITGA4L; RLC
Species Homo sapiens
Ensembl Gene ENSG00000144668
Encoded Proteins
IDBP-25126
integrin, alpha 9
IDBP-371422
integrin, alpha 9
IDBP-371437
integrin, alpha 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:37452115-37823514
Strand Forward strand
Band p22.2
Transcripts
ENST00000264741 ENSP00000264741
ENST00000422441 ENSP00000397258
ENST00000411817 ENSP00000406533
ENST00000461533
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0043236 laminin binding
GO:0046872 metal ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0042060 wound healing
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0034679 alpha9-beta1 integrin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039115
View Gene Order
ENSBTAG00000016566
Not yet available
Pathways
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_18266
Axon guidance pathway
REACT_163906
ECM proteoglycans pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_cs_pathway
Integrin family cell surface interactions
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.113157
RefSeq NM_002207
HUGO
OMIM
CCDS CCDS2669
HPRD 04910
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca