InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA9

Summary

InnateDB Protein

IDBP-25126.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA9

Protein Name

integrin, alpha 9

Synonyms

ALPHA-RLC; ITGA4L; RLC;

Species

Homo sapiens

Ensembl Protein

ENSP00000264741

InnateDB Gene

IDBG-25124 (ITGA9)

Protein Structure

UniProt Annotation

Function

Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0043236	laminin binding
GO:0046872	metal ion binding

Biological Process

GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0042060	wound healing