Version 5.4
Homo sapiens Gene: TAOK2
Summary
InnateDB Gene IDBG-25151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAOK2
Gene Name TAO kinase 2
Synonyms MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2
Species Homo sapiens
Ensembl Gene ENSG00000149930
Encoded Proteins
IDBP-25153
TAO kinase 2
IDBP-25155
TAO kinase 2
IDBP-374779
TAO kinase 2
IDBP-598489
TAO kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:29973641-29992261
Strand Forward strand
Band p11.2
Transcripts
ENST00000279394 ENSP00000279394
ENST00000308893 ENSP00000310094
ENST00000416441 ENSP00000393048
ENST00000543033 ENSP00000440336
ENST00000566552
ENST00000570844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031434 mitogen-activated protein kinase kinase binding
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001558 regulation of cell growth
GO:0006468 protein phosphorylation
GO:0006612 protein targeting to membrane
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0006974 cellular response to DNA damage stimulus
GO:0008360 regulation of cell shape
GO:0016477 cell migration
GO:0030036 actin cytoskeleton organization
GO:0031572 G2 DNA damage checkpoint
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0046330 positive regulation of JNK cascade
GO:0048041 focal adhesion assembly
GO:0051403 stress-activated MAPK cascade
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059981
View Gene Order
ENSBTAG00000017422
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.291623
RefSeq NM_001252043 NM_004783 NM_016151
HUGO
OMIM
CCDS CCDS10662 CCDS10663 CCDS58448
HPRD 18147
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca