InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAOK2

Summary

InnateDB Protein

IDBP-374779.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAOK2

Protein Name

TAO kinase 2

Synonyms

MAP3K17; PSK; PSK1; PSK1-BETA; TAO1; TAO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000393048

InnateDB Gene

IDBG-25151 (TAOK2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. {ECO:0000269PubMed:10660600, ECO:0000269PubMed:11279118, ECO:0000269PubMed:12639963, ECO:0000269PubMed:12665513, ECO:0000269PubMed:13679851, ECO:0000269PubMed:16893890, ECO:0000269PubMed:17158878, ECO:0000269PubMed:17396146}.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full- length isoform 1 are excluded from the nucleus.Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with a higher level of expression in testis and brain. {ECO:0000269PubMed:10660600, ECO:0000269PubMed:13679851}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001558	regulation of cell growth
GO:0006468	protein phosphorylation
GO:0006612	protein targeting to membrane
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0006974	cellular response to DNA damage stimulus
GO:0008360	regulation of cell shape
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0031572	G2 DNA damage checkpoint
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0046330	positive regulation of JNK cascade
GO:0048041	focal adhesion assembly
GO:0051403	stress-activated MAPK cascade

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030425	dendrite
GO:0030659	cytoplasmic vesicle membrane
GO:0043235	receptor complex