Homo sapiens Gene: MSC
Summary
InnateDB Gene IDBG-25188.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSC
Gene Name musculin
Synonyms ABF-1; ABF1; bHLHa22; MYOR;
Species Homo sapiens
Ensembl Gene ENSG00000178860
Encoded Proteins
musculin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:71841549-71844468
Strand Reverse strand
Band q13.3
Transcripts
ENST00000325509 ENSP00000321445
ENST00000518440
ENST00000521739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0014707 branchiomeric skeletal muscle development
GO:0060021 palate development
GO:0060539 diaphragm development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O60682
TrEMBL
UniProt Splice Variant
Entrez Gene 9242
UniGene Hs.442619
RefSeq NM_005098
HUGO HGNC:7321
OMIM 603628
CCDS CCDS43746
HPRD
IMGT
EMBL AF060154 AF087036 BC006313 BC067827 BT007169 CH471068
GenPept AAC15071 AAC69870 AAH06313 AAH67827 AAP35833 EAW86984
RNA Seq Atlas 9242