InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MSC

Summary

InnateDB Protein

IDBP-25190.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSC

Protein Name

musculin

Synonyms

ABF-1; ABF1; bHLHa22; MYOR;

Species

Homo sapiens

Ensembl Protein

ENSP00000321445

InnateDB Gene

IDBG-25188 (MSC)

Protein Structure

UniProt Annotation

Function

Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in lymphoid tissues, B-cell lines and activated B-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0014707	branchiomeric skeletal muscle development
GO:0060021	palate development
GO:0060539	diaphragm development