Homo sapiens Gene: CXCL11
Summary
InnateDB Gene IDBG-25238.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL11
Gene Name chemokine (C-X-C motif) ligand 11
Synonyms b-R1; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B;
Species Homo sapiens
Ensembl Gene ENSG00000169248
Encoded Proteins
chemokine (C-X-C motif) ligand 11
chemokine (C-X-C motif) ligand 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CXCL11 exert direct antimicrobial effects in vitro against Bacillus anthracis spore and bacilli in a receptor-independent manner and contributes to pulmonary innate immunity. (Demonstrated in murine model)
Entrez Gene
Summary Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq, Jul 2008]
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:76033682-76041415
Strand Reverse strand
Band q21.1
Transcripts
ENST00000306621 ENSP00000306884
ENST00000503860 ENSP00000425819
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 9 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0010818 T cell chemotaxis
GO:0030816 positive regulation of cAMP metabolic process
GO:0042127 regulation of cell proliferation
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
Toll-like receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
CXCR3-mediated signaling events
Cross-References
SwissProt O14625
TrEMBL Q96KF0
UniProt Splice Variant
Entrez Gene 6373
UniGene Hs.632592
RefSeq NM_005409
HUGO HGNC:10638
OMIM 604852
CCDS CCDS3574
HPRD 05329
IMGT
EMBL AF002985 AF030514 AF053972 AF077867 AF352781 BC005292 BC012532 BC110986 BT006787 U59286 U66096 Y15220 Y15221
GenPept AAB17374 AAC39775 AAC51845 AAD10206 AAD38327 AAD38867 AAH05292 AAH12532 AAI10987 AAK52900 AAP35433 CAA75510 CAB51859
RNA Seq Atlas 6373