Version 5.4
Homo sapiens Gene: CTSH
Summary
InnateDB Gene IDBG-25289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSH
Gene Name cathepsin H
Synonyms ACC-4; ACC-5; CPSB; minichain;
Species Homo sapiens
Ensembl Gene ENSG00000103811
Encoded Proteins
IDBP-25291
cathepsin H
IDBP-584205
cathepsin H
IDBP-600477
cathepsin H
IDBP-598996
cathepsin H
IDBP-597778
cathepsin H
IDBP-810177
cathepsin H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18762176
Cathepsins: key modulators of cell death and inflammatory responses
Entrez Gene
Summary The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78921058-78949574
Strand Reverse strand
Band q25.1
Transcripts
ENST00000220166 ENSP00000220166
ENST00000527715
ENST00000525807 ENSP00000432935
ENST00000533777 ENSP00000431879
ENST00000534237
ENST00000534533
ENST00000527138
ENST00000529612
ENST00000529861 ENSP00000432893
ENST00000528741 ENSP00000435329
ENST00000529263
ENST00000528191
ENST00000534038
ENST00000530010
ENST00000530929
ENST00000534268
ENST00000528436
ENST00000615999 ENSP00000483303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016505 peptidase activator activity involved in apoptotic process
GO:0030108 HLA-A specific activating MHC class I receptor activity
GO:0030984 kininogen binding
GO:0032403 protein complex binding
GO:0043621 protein self-association
GO:0070324 thyroid hormone binding
Biological Process
GO:0001656 metanephros development
GO:0001913 T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002764 immune response-regulating signaling pathway
GO:0006508 proteolysis
GO:0007283 spermatogenesis
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010813 neuropeptide catabolic process
GO:0010815 bradykinin catabolic process
GO:0010952 positive regulation of peptidase activity
GO:0019882 antigen processing and presentation
GO:0030335 positive regulation of cell migration
GO:0031638 zymogen activation
GO:0031648 protein destabilization
GO:0032526 response to retinoic acid
GO:0033619 membrane protein proteolysis
GO:0043066 negative regulation of apoptotic process
GO:0043129 surfactant homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0060448 dichotomous subdivision of terminal units involved in lung branching
GO:0070371 ERK1 and ERK2 cascade
GO:0097067 cellular response to thyroid hormone stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0001520 outer dense fiber
GO:0001669 acrosomal vesicle
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005930 axoneme
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000032359
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000010992
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148641 Hs.669607
RefSeq NM_004390
HUGO
OMIM
CCDS CCDS10308
HPRD 00288
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca