Bos taurus Gene: CTSH
Summary
InnateDB Gene IDBG-630170.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSH
Gene Name Pro-cathepsin H Cathepsin H mini chain Cathepsin H Cathepsin H heavy chain Cathepsin H light chain
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010992
Encoded Proteins
Pro-cathepsin HCathepsin H mini chainCathepsin HCathepsin H heavy chainCathepsin H light chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Cathepsins: key modulators of cell death and inflammatory responses
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103811:
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:25675908-25696632
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014593 ENSBTAP00000014593
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0016505 peptidase activator activity involved in apoptotic process
GO:0016787 hydrolase activity
GO:0030108 HLA-A specific activating MHC class I receptor activity
GO:0070324 thyroid hormone binding
Biological Process
GO:0001656 metanephros development
GO:0001913 T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002764 immune response-regulating signaling pathway
GO:0006508 proteolysis
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010813 neuropeptide catabolic process
GO:0010815 bradykinin catabolic process
GO:0010952 positive regulation of peptidase activity
GO:0030335 positive regulation of cell migration
GO:0031638 zymogen activation
GO:0031648 protein destabilization
GO:0032526 response to retinoic acid
GO:0033619 membrane protein proteolysis
GO:0043066 negative regulation of apoptotic process
GO:0043129 surfactant homeostasis
GO:0045766 positive regulation of angiogenesis
GO:0060448 dichotomous subdivision of terminal units involved in lung branching
GO:0070371 ERK1 and ERK2 cascade
GO:0097067 cellular response to thyroid hormone stimulus
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Lysosome pathway
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q3T0I2
TrEMBL
UniProt Splice Variant
Entrez Gene 510524
UniGene Bt.52393
RefSeq NM_001034385
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102386
GenPept AAI02387
RNA Seq Atlas 510524