Homo sapiens Gene: TNFSF13
Summary
InnateDB Gene IDBG-25388.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF13
Gene Name tumor necrosis factor (ligand) superfamily, member 13
Synonyms APRIL; CD256; TALL-2; TALL2; TRDL-1; ZTNF2;
Species Homo sapiens
Ensembl Gene ENSG00000161955
Encoded Proteins
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
tumor necrosis factor (ligand) superfamily, member 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7558292-7561608
Strand Forward strand
Band p13.1
Transcripts
ENST00000338784 ENSP00000343505
ENST00000349228 ENSP00000314455
ENST00000380535 ENSP00000369908
ENST00000396545 ENSP00000379794
ENST00000396542 ENSP00000379792
ENST00000438470 ENSP00000390771
ENST00000436057 ENSP00000410094
ENST00000483039 ENSP00000464998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0002426 immunoglobulin production in mucosal tissue
GO:0002636 positive regulation of germinal center formation
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0016064 immunoglobulin mediated immune response
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0050776 regulation of immune response
Cellular Component
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HuR stabilizes mRNA pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Gene Expression pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Intestinal immune network for IgA production pathway
INOH
PID BIOCARTA
Induction of apoptosis through dr3 and dr4/5 death receptors [Biocarta view]
Yaci and bcma stimulation of b cell immune responses [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL K7EJ28
UniProt Splice Variant
Entrez Gene 8741
UniGene Hs.54673 Hs.579197
RefSeq NM_003808 NM_001198624 NM_172087 NM_172088 NM_001198622 NM_001198623
HUGO HGNC:11928
OMIM 604472
CCDS CCDS11111 CCDS56019 CCDS11112 CCDS42256 CCDS73957
HPRD
IMGT
EMBL AC016876
GenPept
RNA Seq Atlas 8741