InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL7

Summary

InnateDB Gene

IDBG-25509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL7

Gene Name

ribosomal protein L7

Synonyms

humL7-1; L7

Species

Homo sapiens

Ensembl Gene

ENSG00000147604

Encoded Proteins

IDBP-25511

ribosomal protein L7

IDBP-237436

ribosomal protein L7

IDBP-237438

ribosomal protein L7

IDBP-237440

ribosomal protein L7

IDBP-372486

ribosomal protein L7

IDBP-372490

ribosomal protein L7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:73290267-73295789

Strand

Reverse strand

Band

q21.11

Transcripts

ENST00000352983	ENSP00000339795
ENST00000396467	ENSP00000379731
ENST00000396466	ENSP00000379730
ENST00000396465	ENSP00000379729
ENST00000435330	ENSP00000415808
ENST00000431653	ENSP00000401300
ENST00000487500
ENST00000466821

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 152 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	152 [view]
Protein-Protein	151 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0042273	ribosomal large subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome