InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCL2A1

Summary

InnateDB Gene

IDBG-25591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2A1

Gene Name

BCL2-related protein A1

Synonyms

ACC-1; ACC-2; BCL2L5; BFL1; GRS; HBPA1

Species

Homo sapiens

Ensembl Gene

ENSG00000140379

Encoded Proteins

IDBP-25593

BCL2-related protein A1

IDBP-25595

BCL2-related protein A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21167304

BCL2A1 negatively regulates autophagy and expression of BCL2A1 in Mycobacterium tuberculosis infected macrophages provides the bacteria a survival strategy to overcome host defences.

Entrez Gene

Summary

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:79960889-79971446

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000267953	ENSP00000267953
ENST00000335661	ENSP00000335250

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	22 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051400	BH domain binding

Biological Process

GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005741

mitochondrial outer membrane

Orthologs

Species

Bos taurus

Mus musculus

Gene ID

Gene Order

ENSBTAG00000000735

Not yet available

null

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

bcr_5pathway

BCR signaling pathway

Cross-References

SwissProt

Q16548

TrEMBL

UniProt Splice Variant

Entrez Gene

597

UniGene

RefSeq

NM_001114735 NM_004049

HUGO

HGNC:991

OMIM

601056

CCDS

CCDS10312 CCDS45322

HPRD

IMGT

EMBL

AC015871 AY234180 BC016281 BT007103 CH471136 CR541937 CR541962 U27467 U29680 Y09397

GenPept

AAC50288 AAC50438 AAH16281 AAO89009 AAP35767 CAA70566 CAG46735 CAG46760 EAW99129

RNA Seq Atlas

597