InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BCL2A1

Summary

InnateDB Gene

IDBG-630216.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2A1

Gene Name

Bcl-2-related protein A1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000735

Encoded Proteins

IDBP-681656

Bcl-2-related protein A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21167304

[Homo sapiens] BCL2A1 negatively regulates autophagy and expression of BCL2A1 in Mycobacterium tuberculosis infected macrophages provides the bacteria a survival strategy to overcome host defences.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140379:
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:26481215-26490869

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000977

ENSBTAP00000000977

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006915	apoptotic process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000140379

View Gene Order

null

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

bcr_5pathway

BCR signaling pathway

Cross-References

SwissProt

Q3C2I0

TrEMBL

UniProt Splice Variant

Entrez Gene

282151

UniGene

Bt.11884

RefSeq

NM_001037100 XM_005221868

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB195549 BC123574

GenPept

AAI23575 BAE46584

RNA Seq Atlas

282151