|Bos taurus Gene: BCL2A1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||Bcl-2-related protein A1|
Bcl-2-related protein A1
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Homo sapiens] BCL2A1 negatively regulates autophagy and expression of BCL2A1 in Mycobacterium tuberculosis infected macrophages provides the bacteria a survival strategy to overcome host defences.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140379:
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 21:26481215-26490869|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
BCR signaling pathway
|UniProt Splice Variant|
|RNA Seq Atlas||282151|