Homo sapiens Gene: MMP11
Summary
InnateDB Gene IDBG-2572.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MMP11
Gene Name matrix metallopeptidase 11 (stromelysin 3)
Synonyms SL-3; ST3; STMY3;
Species Homo sapiens
Ensembl Gene ENSG00000099953
Encoded Proteins
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 11 (stromelysin 3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP\'s, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:23768226-23784316
Strand Forward strand
Band q11.23
Transcripts
ENST00000215743 ENSP00000215743
ENST00000428253 ENSP00000409860
ENST00000437086 ENSP00000408070
ENST00000434318 ENSP00000412107
ENST00000465385
ENST00000477567
ENST00000489582
ENST00000465730
ENST00000460352
ENST00000493132
ENST00000492464
ENST00000488363
ENST00000480185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030574 collagen catabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0071711 basement membrane organization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005796 Golgi lumen
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
Collagen degradation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WDI7
UniProt Splice Variant
Entrez Gene 4320
UniGene Hs.143751
RefSeq NM_005940
HUGO HGNC:7157
OMIM 185261
CCDS CCDS13816
HPRD 01705
IMGT
EMBL AP000349
GenPept
RNA Seq Atlas 102725056 4320