InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP11

Summary

InnateDB Protein

IDBP-2574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP11

Protein Name

matrix metallopeptidase 11 (stromelysin 3)

Synonyms

SL-3; ST3; STMY3;

Species

Homo sapiens

Ensembl Protein

ENSP00000215743

InnateDB Gene

IDBG-2572 (MMP11)

Protein Structure

UniProt Annotation

Function

May play an important role in the progression of epithelial malignancies.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in stromal cells of breast carcinomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007275	multicellular organismal development
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030574	collagen catabolic process
GO:0045599	negative regulation of fat cell differentiation
GO:0071711	basement membrane organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005796	Golgi lumen
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References