Homo sapiens Gene: CXCL13
Summary
InnateDB Gene IDBG-25774.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CXCL13
Gene Name chemokine (C-X-C motif) ligand 13
Synonyms ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13;
Species Homo sapiens
Ensembl Gene ENSG00000156234
Encoded Proteins
chemokine (C-X-C motif) ligand 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Jul 2008]
B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer\'s patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt\'s lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:77511753-77611834
Strand Forward strand
Band q21.1
Transcripts
ENST00000286758 ENSP00000286758
ENST00000506590
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 9 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
GO:0031724 CXCR5 chemokine receptor binding
GO:0031735 CCR10 chemokine receptor binding
GO:0046982 protein heterodimerization activity
GO:0048018 receptor agonist activity
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0002467 germinal center formation
GO:0002518 lymphocyte chemotaxis across high endothelial venule
GO:0002544 chronic inflammatory response
GO:0002920 regulation of humoral immune response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0010820 positive regulation of T cell chemotaxis
GO:0032861 activation of Rap GTPase activity
GO:0033625 positive regulation of integrin activation
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0035754 B cell chemotaxis
GO:0035768 endothelial cell chemotaxis to fibroblast growth factor
GO:0035769 B cell chemotaxis across high endothelial venule
GO:0042742 defense response to bacterium
GO:0045765 regulation of angiogenesis
GO:0048535 lymph node development
GO:2000545 negative regulation of endothelial cell chemotaxis to fibroblast growth factor
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
CXCR3-mediated signaling events
Cross-References
SwissProt O43927
TrEMBL Q53X90
UniProt Splice Variant
Entrez Gene 10563
UniGene Hs.100431
RefSeq NM_006419 XM_006714063
HUGO HGNC:10639
OMIM 605149
CCDS CCDS3582
HPRD 05513
IMGT
EMBL AC093758 AF029894 AF044197 AJ002211 BC012589 CH471057 CR407624 EF064743
GenPept AAC14402 AAC17980 AAH12589 AAY40955 ABK41926 CAA05250 CAG28552 EAX05816 EAX05817
RNA Seq Atlas 10563