Version 5.4
Mus musculus Gene: Capn3
Summary
InnateDB Gene IDBG-259652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capn3
Gene Name calpain 3
Synonyms AI323605; Capa-3; Capa3; Lp82; p94
Species Mus musculus
Ensembl Gene ENSMUSG00000079110
Encoded Proteins
IDBP-200845
calpain 3
IDBP-200847
calpain 3
IDBP-200849
calpain 3
IDBP-259654
calpain 3
IDBP-259658
calpain 3
IDBP-259660
calpain 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092529:
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:120456019-120504913
Strand Forward strand
Band E5
Transcripts
ENSMUST00000090028 ENSMUSP00000087482
ENSMUST00000028749 ENSMUSP00000028749
ENSMUST00000028748 ENSMUSP00000028748
ENSMUST00000110721 ENSMUSP00000106349
ENSMUST00000110719 ENSMUSP00000106347
ENSMUST00000110716 ENSMUSP00000106344
ENSMUST00000145993
ENSMUST00000124129
ENSMUST00000139336
ENSMUST00000151924
ENSMUST00000125238
ENSMUST00000141181
ENSMUST00000151342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008307 structural constituent of muscle
GO:0031402 sodium ion binding
GO:0031432 titin binding
GO:0032947 protein complex scaffold
GO:0055103 ligase regulator activity
Biological Process
GO:0001896 autolysis
GO:0006461 protein complex assembly
GO:0006508 proteolysis
GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration
GO:0014850 response to muscle activity
GO:0030239 myofibril assembly
GO:0033234 negative regulation of protein sumoylation
GO:0043066 negative regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045214 sarcomere organization
GO:0045661 regulation of myoblast differentiation
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050790 regulation of catalytic activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051592 response to calcium ion
GO:0061061 muscle structure development
GO:0070315 G1 to G0 transition involved in cell differentiation
GO:0071277 cellular response to calcium ion
GO:0071472 cellular response to salt stress
GO:0072657 protein localization to membrane
GO:0097264 self proteolysis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030016 myofibril
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092529
View Gene Order
ENSBTAG00000008868
Not yet available
Cross-References
SwissProt Q64691
TrEMBL Q920R8
UniProt Splice Variant
Entrez Gene 12335
UniGene Mm.458021
RefSeq NM_001177799 NM_001109761 NM_007601
OMIM
CCDS CCDS50679 CCDS16620 CCDS50680
HPRD
IMGT
MGI ID MGI:107437
MGI Symbol Capn3
EMBL AB050200 AF127766 AL935121 X92523
GenPept AAD28255 BAB70478 CAA63301 CAM24140
RNA Seq Atlas 12335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca