Homo sapiens Gene: HBG2
Summary
InnateDB Gene IDBG-26431.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HBG2
Gene Name hemoglobin, gamma G
Synonyms HBG-T1; TNCY;
Species Homo sapiens
Ensembl Gene ENSG00000196565
Encoded Proteins
hemoglobin, gamma G
hemoglobin, gamma G
hemoglobin, gamma G
hemoglobin, gamma G
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5\'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3\'. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5248274-5645789
Strand Reverse strand
Band p15.4
Transcripts
ENST00000380259 ENSP00000369609
ENST00000380252 ENSP00000369602
ENST00000336906 ENSP00000338082
ENST00000444587
ENST00000620888 ENSP00000479637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005344 oxygen transporter activity
GO:0005506 iron ion binding
GO:0019825 oxygen binding
GO:0020037 heme binding
Biological Process
GO:0007596 blood coagulation
GO:0015671 oxygen transport
Cellular Component
GO:0005829 cytosol
GO:0005833 hemoglobin complex
GO:0072562 blood microparticle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
ATF-2 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.302145
RefSeq NM_000184
HUGO
OMIM
CCDS CCDS7755
HPRD 00792
IMGT
EMBL
GenPept
RNA Seq Atlas