Version 5.4
Homo sapiens Gene: CELF4
Summary
InnateDB Gene IDBG-2659.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CELF4
Gene Name CUGBP, Elav-like family member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101489
Encoded Proteins
IDBP-2661
CUGBP, Elav-like family member 4
IDBP-2663
CUGBP, Elav-like family member 4
IDBP-368204
CUGBP, Elav-like family member 4
IDBP-725879
IDBP-725827
IDBP-726419
IDBP-726671
IDBP-728063
IDBP-725919
IDBP-725923
IDBP-727590
IDBP-725648
IDBP-728107
IDBP-726801
IDBP-727714
IDBP-725961
IDBP-725626
IDBP-726524
IDBP-808640
CUGBP, Elav-like family member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:37243047-37566037
Strand Reverse strand
Band q12.2
Transcripts
ENST00000361795 ENSP00000355089
ENST00000334919 ENSP00000335631
ENST00000420428 ENSP00000410584
ENST00000588597 ENSP00000468109
ENST00000591421
ENST00000591282 ENSP00000464794
ENST00000587911 ENSP00000471616
ENST00000591287 ENSP00000464917
ENST00000589386 ENSP00000465125
ENST00000593271 ENSP00000464996
ENST00000589229 ENSP00000465211
ENST00000586009 ENSP00000465348
ENST00000587074
ENST00000601019 ENSP00000469627
ENST00000587449
ENST00000588591 ENSP00000468256
ENST00000590011
ENST00000601392 ENSP00000470649
ENST00000590112 ENSP00000468428
ENST00000587657 ENSP00000467056
ENST00000587819 ENSP00000467732
ENST00000587924 ENSP00000467571
ENST00000603232 ENSP00000474788
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003676 nucleic acid binding
GO:0003729 mRNA binding
GO:0042835 BRE binding
Biological Process
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006376 mRNA splice site selection
GO:0007281 germ cell development
GO:0009790 embryo development
GO:0017148 negative regulation of translation
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0090394 negative regulation of excitatory postsynaptic membrane potential
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024268
View Gene Order
ENSBTAG00000004940
Not yet available
Cross-References
SwissProt
TrEMBL K7ENR2
UniProt Splice Variant
Entrez Gene 56853
UniGene Hs.435976 Hs.600908 Hs.602283
RefSeq NM_001025087 NM_001025088 NM_001025089 NM_020180 XM_005258308 XM_006722509
HUGO HGNC:14015
OMIM 612679
CCDS CCDS32818 CCDS45857 CCDS45858
HPRD 12534
IMGT
EMBL AC015961 AC090386 AC093332 AC129908
GenPept
RNA Seq Atlas 56853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca