Homo sapiens Gene: CDK6
Summary
InnateDB Gene IDBG-26773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK6
Gene Name cyclin-dependent kinase 6
Synonyms PLSTIRE;
Species Homo sapiens
Ensembl Gene ENSG00000105810
Encoded Proteins
cyclin-dependent kinase 6
cyclin-dependent kinase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CDK6 expression is induced upon LPS stimulation via TLR4-signalling pathway. CDK6 mediates the increased adhesion of macrophages in response to LPS challenge, and is important for LPS lethality. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cdk6 expression is induced upon LPS stimulation via Tlr4-signalling pathway. Cdk6 mediates the increased adhesion of macrophages in response to LPS challenge, and is important for LPS lethality.
Entrez Gene
Summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:92604921-92836594
Strand Reverse strand
Band q21.2
Transcripts
ENST00000265734 ENSP00000265734
ENST00000424848 ENSP00000397087
ENST00000467166
ENST00000473078
ENST00000491250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 135 [view]
Protein-Protein 127 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001954 positive regulation of cell-matrix adhesion
GO:0003323 type B pancreatic cell development
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0010468 regulation of gene expression
GO:0014002 astrocyte development
GO:0021542 dentate gyrus development
GO:0021670 lateral ventricle development
GO:0042063 gliogenesis
GO:0043697 cell dedifferentiation
GO:0045087 innate immune response (InnateDB)
GO:0045596 negative regulation of cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045646 regulation of erythrocyte differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0048146 positive regulation of fibroblast proliferation
GO:0048699 generation of neurons
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051301 cell division
GO:2000145 regulation of cell motility
GO:2000773 negative regulation of cellular senescence
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
Wnt pathway
BCR pathway
REACTOME
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Mitotic G1-G1/S phases pathway
Cyclin D associated events in G1 pathway
Cell Cycle pathway
Cellular Senescence pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Oxidative Stress Induced Senescence pathway
KEGG
Cell cycle pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Glioma pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Cell cycle: g1/s check point [Biocarta view]
Estrogen responsive protein efp controls cell cycle and breast tumors growth [Biocarta view]
Cyclins and cell cycle regulation [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Coregulation of Androgen receptor activity
p73 transcription factor network
C-MYB transcription factor network
IL2 signaling events mediated by STAT5
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.119882 Hs.594280 Hs.606869 Hs.612501 Hs.708472
RefSeq NM_001145306 NM_001259 XM_006715835
HUGO
OMIM
CCDS CCDS5628
HPRD 04533
IMGT
EMBL
GenPept
RNA Seq Atlas