InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CALCR

Summary

InnateDB Gene

IDBG-27060.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCR

Gene Name

calcitonin receptor

Synonyms

CRT; CT-R; CTR; CTR1

Species

Homo sapiens

Ensembl Gene

ENSG00000004948

Encoded Proteins

IDBP-27062

calcitonin receptor

IDBP-27064

calcitonin receptor

IDBP-241566

calcitonin receptor

IDBP-381956

calcitonin receptor

IDBP-381965

calcitonin receptor

IDBP-381972

calcitonin receptor

IDBP-381973

calcitonin receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:93424487-93574730

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000359558	ENSP00000352561
ENST00000360249	ENSP00000353385
ENST00000394441	ENSP00000377959
ENST00000421592	ENSP00000399552
ENST00000426151	ENSP00000389295
ENST00000423724	ENSP00000391369
ENST00000415529	ENSP00000413179

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0032841	calcitonin binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0015031	protein transport
GO:0030279	negative regulation of ossification
GO:0030316	osteoclast differentiation
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0043488	regulation of mRNA stability
GO:0045762	positive regulation of adenylate cyclase activity
GO:0051384	response to glucocorticoid
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023964

View Gene Order

ENSBTAG00000017458

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_18290

Calcitonin-like ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.489127

RefSeq

NM_001164737 NM_001164738 NM_001742

HUGO

OMIM

CCDS

CCDS55125 CCDS5631

HPRD

00239

IMGT

EMBL

GenPept

RNA Seq Atlas