Version 5.4
Homo sapiens Gene: ENTPD3
Summary
InnateDB Gene IDBG-27094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENTPD3
Gene Name ectonucleoside triphosphate diphosphohydrolase 3
Synonyms CD39L3; HB6; NTPDase-3
Species Homo sapiens
Ensembl Gene ENSG00000168032
Encoded Proteins
IDBP-27096
ectonucleoside triphosphate diphosphohydrolase 3
IDBP-373022
ectonucleoside triphosphate diphosphohydrolase 3
IDBP-373025
ectonucleoside triphosphate diphosphohydrolase 3
IDBP-373026
ectonucleoside triphosphate diphosphohydrolase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jul 2008]
This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:40387156-40428619
Strand Forward strand
Band p22.1
Transcripts
ENST00000301825 ENSP00000301825
ENST00000456402 ENSP00000401565
ENST00000439533 ENSP00000406555
ENST00000445129 ENSP00000404671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0008152 metabolic process
GO:0009134 nucleoside diphosphate catabolic process
GO:0009143 nucleoside triphosphate catabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041608
View Gene Order
ENSBTAG00000011702
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.441145
RefSeq NM_001248 NM_001291960 NM_001291961 XM_005265606 XM_005265607 XM_005265608 XM_006713422
HUGO
OMIM
CCDS CCDS2691 CCDS74919
HPRD 16014
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca