Homo sapiens Gene: BNC1
Summary
InnateDB Gene IDBG-27171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BNC1
Gene Name basonuclin 1
Synonyms BNC; BSN1; HsT19447;
Species Homo sapiens
Ensembl Gene ENSG00000169594
Encoded Proteins
basonuclin 1
basonuclin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:83255903-83284716
Strand Reverse strand
Band q25.2
Transcripts
ENST00000345382 ENSP00000307041
ENST00000569704 ENSP00000456727
ENST00000618086 ENSP00000478817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0042060 wound healing
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q01954
TrEMBL F5GY04
UniProt Splice Variant
Entrez Gene 646
UniGene Hs.459153
RefSeq NM_001301206 NM_001717 XM_005272447 XM_006720641
HUGO HGNC:1081
OMIM 601930
CCDS CCDS10324 CCDS73771
HPRD
IMGT
EMBL AC103876 L03427 U59692 U59693 U59694
GenPept AAA35584 AAB53028
RNA Seq Atlas 646