Homo sapiens Gene: CTNNB1
Summary
InnateDB Gene IDBG-27347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNB1
Gene Name catenin (cadherin-associated protein), beta 1, 88kDa
Synonyms armadillo; CTNNB; MRD19;
Species Homo sapiens
Ensembl Gene ENSG00000168036
Encoded Proteins
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
catenin (cadherin-associated protein), beta 1, 88kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CTNNB1 binds to NFKB1 and regulates expression of C-Reactive protein (CRP) after TNF (TNF-alpha) treatment.
CTNNB1 interacts with LRRFIP1, promoting the activation of CTNNB1, which increases IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase EP300 to the IFN-beta enhanceosome via IRF3.
Stabilization of CTNNB1 upon virus infection negatively regulates antiviral innate immunity.
Glycogen synthase kinase 3/CTNNB1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Glycogen synthase kinase 3/Ctnnb1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
Entrez Gene
Summary The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:41194837-41260096
Strand Forward strand
Band p22.1
Transcripts
ENST00000349496 ENSP00000344456
ENST00000396185 ENSP00000379488
ENST00000396183 ENSP00000379486
ENST00000405570 ENSP00000385604
ENST00000426215 ENSP00000400508
ENST00000433400 ENSP00000387455
ENST00000431914 ENSP00000412219
ENST00000453024 ENSP00000411226
ENST00000450969 ENSP00000409302
ENST00000441708 ENSP00000401599
ENST00000488914
ENST00000465552
ENST00000482042
ENST00000485265
ENST00000471014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 603 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.
Experimentally validated
Total 603 [view]
Protein-Protein 554 [view]
Protein-DNA 38 [view]
Protein-RNA 0
DNA-DNA 11 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 106 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030331 estrogen receptor binding
GO:0032403 protein complex binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0044325 ion channel binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0046332 SMAD binding
GO:0050681 androgen receptor binding
GO:0050998 nitric-oxide synthase binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000578 embryonic axis specification
GO:0000904 cell morphogenesis involved in differentiation
GO:0001501 skeletal system development
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001711 endodermal cell fate commitment
GO:0001764 neuron migration
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001840 neural plate development
GO:0001889 liver development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002089 lens morphogenesis in camera-type eye
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007268 synaptic transmission
GO:0007398 ectoderm development
GO:0007403 glial cell fate determination
GO:0007494 midgut development
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009725 response to hormone
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009987 cellular process
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 Schwann cell proliferation
GO:0014070 response to organic cyclic compound
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0016337 single organismal cell-cell adhesion
GO:0021819 layer formation in cerebral cortex
GO:0022009 central nervous system vasculogenesis
GO:0022405 hair cycle process
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0030316 osteoclast differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030521 androgen receptor signaling pathway
GO:0030539 male genitalia development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0030997 regulation of centriole-centriole cohesion
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0032481 positive regulation of type I interferon production
GO:0033077 T cell differentiation in thymus
GO:0033234 negative regulation of protein sumoylation
GO:0034097 response to cytokine
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0035050 embryonic heart tube development
GO:0035112 genitalia morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035315 hair cell differentiation
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0042127 regulation of cell proliferation
GO:0042129 regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042692 muscle cell differentiation
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043587 tongue morphogenesis
GO:0043588 skin development
GO:0043627 response to estrogen
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045445 myoblast differentiation
GO:0045453 bone resorption
GO:0045595 regulation of cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045765 regulation of angiogenesis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046686 response to cadmium ion
GO:0048145 regulation of fibroblast proliferation
GO:0048262 determination of dorsal/ventral asymmetry
GO:0048469 cell maturation
GO:0048489 synaptic vesicle transport
GO:0048513 organ development
GO:0048538 thymus development
GO:0048599 oocyte development
GO:0048617 embryonic foregut morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050808 synapse organization
GO:0051145 smooth muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051291 protein heterooligomerization
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060479 lung cell differentiation
GO:0060484 lung-associated mesenchyme development
GO:0060492 lung induction
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 hair follicle placode formation
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061154 endothelial tube morphogenesis
GO:0061198 fungiform papilla formation
GO:0061324 canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071260 cellular response to mechanical stimulus
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071681 cellular response to indole-3-methanol
GO:0072001 renal system development
GO:0072033 renal vesicle formation
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072079 nephron tubule formation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0090279 regulation of calcium ion import
GO:1901215 negative regulation of neuron death
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:2000008 regulation of protein localization to cell surface
GO:2000017 positive regulation of determination of dorsal identity
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005916 fascia adherens
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030057 desmosome
GO:0030877 beta-catenin destruction complex
GO:0031253 cell projection membrane
GO:0031528 microvillus membrane
GO:0032993 protein-DNA complex
GO:0034750 Scrib-APC-beta-catenin complex
GO:0043005 neuron projection
GO:0043198 dendritic shaft
GO:0043234 protein complex
GO:0043296 apical junction complex
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071664 catenin-TCF7L2 complex
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
AndrogenReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
Hedgehog pathway
TCR pathway
BCR pathway
IL5 pathway
TWEAK pathway
REACTOME
truncated APC mutants destabilize the destruction complex pathway
Developmental Biology pathway
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Ca2+ pathway pathway
CDO in myogenesis pathway
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
Innate Immune System pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
Myogenesis pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Immune System pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Cytosolic sensors of pathogen-associated DNA pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Melanogenesis pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Pathways in cancer pathway
Colorectal cancer pathway
Endometrial cancer pathway
Prostate cancer pathway
Thyroid cancer pathway
Basal cell carcinoma pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
Wnt signaling pathway pathway
PID BIOCARTA
Segmentation clock [Biocarta view]
Cell to cell adhesion signaling [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Multi-step regulation of transcription by pitx2 [Biocarta view]
Wnt signaling pathway [Biocarta view]
PID NCI
E-cadherin signaling events
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Coregulation of Androgen receptor activity
Presenilin action in Notch and Wnt signaling
Nectin adhesion pathway
FoxO family signaling
Regulation of nuclear beta catenin signaling and target gene transcription
Integrin-linked kinase signaling
AP-1 transcription factor network
RAC1 signaling pathway
CDC42 signaling events
Signaling events mediated by VEGFR1 and VEGFR2
Canonical Wnt signaling pathway
TGF-beta receptor signaling
Degradation of beta catenin
Stabilization and expansion of the E-cadherin adherens junction
Arf6 trafficking events
N-cadherin signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt P35222
TrEMBL A0A024R2Q3 B4DGU4 C9IZ65 E7EMJ5 E7EV28 E9PDF9 G9GAG7
UniProt Splice Variant
Entrez Gene 1499
UniGene Hs.476018 Hs.603944
RefSeq NM_001904 NM_001098210 NM_001098209 XM_006712983 XM_005264886 XM_006712984
HUGO HGNC:2514
OMIM 116806
CCDS CCDS2694
HPRD 00286
IMGT
EMBL AB062292 AC104307 AF130085 AK289932 AK294778 AY081165 AY463360 BC058926 CH471055 JN314422 X87838 Z19054
GenPept AAG35511 AAH58926 AAL89457 AAR18817 AEW16366 BAB93475 BAF82621 BAG57905 CAA61107 CAA79497 EAW64625 EAW64626 EAW64627 EAW64628
RNA Seq Atlas 1499