Version 5.4
Bos taurus Gene: CTNNB1
Summary
InnateDB Gene IDBG-644470.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNNB1
Gene Name Catenin beta-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016420
Encoded Proteins
IDBP-697115
Catenin beta-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17704137
[Homo sapiens] CTNNB1 binds to NFKB1 and regulates expression of C-Reactive protein (CRP) after TNF (TNF-alpha) treatment.
PMID 20453844
[Homo sapiens] CTNNB1 interacts with LRRFIP1, promoting the activation of CTNNB1, which increases IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase EP300 to the IFN-beta enhanceosome via IRF3.
PMID 23785285
[Homo sapiens] Stabilization of CTNNB1 upon virus infection negatively regulates antiviral innate immunity.
PMID 26100021
[Homo sapiens] Glycogen synthase kinase 3/CTNNB1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
PMID 26100021
[Mus musculus] Glycogen synthase kinase 3/Ctnnb1 (β-catenin) axis is required for optimal induction of antiviral innate immunity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168036:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:13842703-13889468
Strand Forward strand
Band
Transcripts
ENSBTAT00000021838 ENSBTAP00000021838
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 420 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 420 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030331 estrogen receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0044212 transcription regulatory region DNA binding
GO:0044325 ion channel binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0046332 SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000578 embryonic axis specification
GO:0000904 cell morphogenesis involved in differentiation
GO:0001501 skeletal system development
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001706 endoderm formation
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001711 endodermal cell fate commitment
GO:0001764 neuron migration
GO:0001822 kidney development
GO:0001840 neural plate development
GO:0001889 liver development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002089 lens morphogenesis in camera-type eye
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007268 synaptic transmission
GO:0007398 ectoderm development
GO:0007403 glial cell fate determination
GO:0007507 heart development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009948 anterior/posterior axis specification
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0009987 cellular process
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 Schwann cell proliferation
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0016337 single organismal cell-cell adhesion
GO:0021819 layer formation in cerebral cortex
GO:0022009 central nervous system vasculogenesis
GO:0022405 hair cycle process
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0030316 osteoclast differentiation
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030539 male genitalia development
GO:0030856 regulation of epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0030997 regulation of centriole-centriole cohesion
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031641 regulation of myelination
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032355 response to estradiol
GO:0033077 T cell differentiation in thymus
GO:0033234 negative regulation of protein sumoylation
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0034613 cellular protein localization
GO:0035050 embryonic heart tube development
GO:0035112 genitalia morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0042127 regulation of cell proliferation
GO:0042129 regulation of T cell proliferation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0043587 tongue morphogenesis
GO:0043588 skin development
GO:0043627 response to estrogen
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045453 bone resorption
GO:0045595 regulation of cell differentiation
GO:0045596 negative regulation of cell differentiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048262 determination of dorsal/ventral asymmetry
GO:0048469 cell maturation
GO:0048489 synaptic vesicle transport
GO:0048513 organ development
GO:0048538 thymus development
GO:0048599 oocyte development
GO:0048617 embryonic foregut morphogenesis
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0050808 synapse organization
GO:0051145 smooth muscle cell differentiation
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060439 trachea morphogenesis
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060479 lung cell differentiation
GO:0060484 lung-associated mesenchyme development
GO:0060492 lung induction
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 hair follicle placode formation
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061154 endothelial tube morphogenesis
GO:0061198 fungiform papilla formation
GO:0061324 canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071681 cellular response to indole-3-methanol
GO:0072001 renal system development
GO:0072033 renal vesicle formation
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072079 nephron tubule formation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0090279 regulation of calcium ion import
GO:1901215 negative regulation of neuron death
GO:2000008 regulation of protein localization to cell surface
GO:2000017 positive regulation of determination of dorsal identity
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005916 fascia adherens
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0009898 cytoplasmic side of plasma membrane
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030057 desmosome
GO:0030877 beta-catenin destruction complex
GO:0031253 cell projection membrane
GO:0031528 microvillus membrane
GO:0032993 protein-DNA complex
GO:0034750 Scrib-APC-beta-catenin complex
GO:0043198 dendritic shaft
GO:0043296 apical junction complex
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0070369 beta-catenin-TCF7L2 complex
GO:0071664 catenin-TCF7L2 complex
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000168036
View Gene Order
ENSMUSG00000006932
View Gene Order
Pathways
NETPATH
REACTOME
REACT_243616
APC truncation mutants have impaired AXIN binding pathway
REACT_212636
Signaling by Wnt pathway
REACT_219628
Apoptotic cleavage of cellular proteins pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_262425
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_210701
Peptide hormone metabolism pathway
REACT_205221
Incretin synthesis, secretion, and inactivation pathway
REACT_216172
Myogenesis pathway
REACT_220974
Cytosolic sensors of pathogen-associated DNA pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_248524
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_203419
deactivation of the beta-catenin transactivating complex pathway
REACT_206064
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_260827
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_246299
VEGFA-VEGFR2 Pathway pathway
REACT_262545
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_213138
Immune System pathway
REACT_242612
truncations of AMER1 destabilize the destruction complex pathway
REACT_245697
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_209727
Ca2+ pathway pathway
REACT_214866
Cell junction organization pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_217581
Beta-catenin phosphorylation cascade pathway
REACT_214353
Signal Transduction pathway
REACT_236208
VEGFR2 mediated vascular permeability pathway
REACT_206475
Cell-Cell communication pathway
REACT_242961
AXIN missense mutants destabilize the destruction complex pathway
REACT_223324
Apoptotic cleavage of cell adhesion proteins pathway
REACT_257729
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_213782
Metabolism of proteins pathway
REACT_206800
beta-catenin independent WNT signaling pathway
REACT_227007
Apoptotic execution phase pathway
REACT_209873
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_247065
TCF7L2 mutants don't bind CTBP pathway
REACT_237056
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_234401
AMER1 mutants destabilize the destruction complex pathway
REACT_226693
Signaling by VEGF pathway
REACT_207240
Cell-cell junction organization pathway
REACT_221627
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207559
CDO in myogenesis pathway
REACT_235327
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_222355
formation of the beta-catenin:TCF transactivating complex pathway
REACT_216714
Innate Immune System pathway
REACT_248525
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_207087
Disease pathway
REACT_203739
Degradation of beta-catenin by the destruction complex pathway
REACT_212282
Adherens junctions interactions pathway
REACT_219454
Apoptosis pathway
REACT_263270
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_220844
Developmental Biology pathway
REACT_236276
truncated APC mutants destabilize the destruction complex pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_10
Hedgehog pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_17
IL5 pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_21402
CDO in myogenesis pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_111045
Developmental Biology pathway
REACT_200799
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_172761
Ca2+ pathway pathway
REACT_163743
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_6802
Innate Immune System pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_21303
Myogenesis pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228106
repression of WNT target genes pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_230557
Incretin synthesis, secretion, and inactivation pathway
REACT_218396
Beta-catenin phosphorylation cascade pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_227951
Signaling by VEGF pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_259776
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_212869
Apoptotic cleavage of cell adhesion proteins pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_248094
Cell-cell junction organization pathway
REACT_230745
Immune System pathway
REACT_253473
Myogenesis pathway
REACT_247926
Metabolism of proteins pathway
REACT_223626
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_219771
deactivation of the beta-catenin transactivating complex pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_258600
CDO in myogenesis pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_230395
Adherens junctions interactions pathway
REACT_261840
VEGFR2 mediated vascular permeability pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_221970
Ca2+ pathway pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_188576
Developmental Biology pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_188257
Signal Transduction pathway
REACT_241978
Cell junction organization pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_223082
Cell-Cell communication pathway
REACT_207035
Apoptotic execution phase pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05216
Thyroid cancer pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa05217
Basal cell carcinoma pathway
hsa04916
Melanogenesis pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04530
Tight junction pathway
mmu05213
Endometrial cancer pathway
mmu05217
Basal cell carcinoma pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu05216
Thyroid cancer pathway
mmu04520
Adherens junction pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu05215
Prostate cancer pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05200
Pathways in cancer pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
Wnt signaling pathway pathway
PID NCI
ecadherin_1_pathway
E-cadherin signaling events
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
ar_pathway
Coregulation of Androgen receptor activity
ps1pathway
Presenilin action in Notch and Wnt signaling
nectin_pathway
Nectin adhesion pathway
foxopathway
FoxO family signaling
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ilk_pathway
Integrin-linked kinase signaling
ap1_pathway
AP-1 transcription factor network
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
wnt_canonical_pathway
Canonical Wnt signaling pathway
tgfbrpathway
TGF-beta receptor signaling
betacatenin_deg_pathway
Degradation of beta catenin
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_traffickingpathway
Arf6 trafficking events
ncadherinpathway
N-cadherin signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt Q0VCX4
TrEMBL
UniProt Splice Variant
Entrez Gene 539003
UniGene Bt.33687 Bt.97652
RefSeq NM_001076141
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119949 BT030683
GenPept AAI19950 ABS44999
RNA Seq Atlas 539003

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca