Version 5.4
Homo sapiens Gene: SETD1A
Summary
InnateDB Gene IDBG-27371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SETD1A
Gene Name SET domain containing 1A
Synonyms KMT2F; Set1; Set1A
Species Homo sapiens
Ensembl Gene ENSG00000099381
Encoded Proteins
IDBP-27373
SET domain containing 1A
IDBP-375659
SET domain containing 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005 [PubMed 16253997]). Also see SET1B (MIM 611055).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30957294-30985116
Strand Forward strand
Band p11.2
Transcripts
ENST00000262519 ENSP00000262519
ENST00000452917 ENSP00000391408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
Experimentally validated
Total 42 [view]
Protein-Protein 38 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0016607 nuclear speck
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042308
View Gene Order
ENSBTAG00000002345
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.297483 Hs.614412
RefSeq NM_014712 XM_005255723 XM_006721106 XM_006721107
HUGO
OMIM
CCDS CCDS32435
HPRD 13795
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca