Homo sapiens Gene: BCKDK
Summary
InnateDB Gene IDBG-27748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCKDK
Gene Name branched chain ketoacid dehydrogenase kinase
Synonyms BCKDKD; BDK;
Species Homo sapiens
Ensembl Gene ENSG00000103507
Encoded Proteins
branched chain ketoacid dehydrogenase kinase
branched chain ketoacid dehydrogenase kinase
branched chain ketoacid dehydrogenase kinase
branched chain ketoacid dehydrogenase kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:31106107-31112791
Strand Forward strand
Band p11.2
Transcripts
ENST00000287507 ENSP00000287507
ENST00000219794 ENSP00000219794
ENST00000394951 ENSP00000378405
ENST00000394950 ENSP00000378404
ENST00000484226 ENSP00000457226
ENST00000567676 ENSP00000454947
ENST00000561755 ENSP00000455866
ENST00000567682 ENSP00000457821
ENST00000566568
ENST00000567530 ENSP00000456479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
Biological Process
GO:0009063 cellular amino acid catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0016310 phosphorylation
Cellular Component
GO:0005739 mitochondrion
GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10295
UniGene Hs.513520
RefSeq NM_001122957 NM_001271926 NM_005881
HUGO HGNC:16902
OMIM 614901
CCDS CCDS10705 CCDS45467 CCDS61917
HPRD 12523
IMGT
EMBL
GenPept
RNA Seq Atlas 10295