Homo sapiens Gene: ADAM17
Summary
InnateDB Gene IDBG-27788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM17
Gene Name ADAM metallopeptidase domain 17
Synonyms ADAM18; CD156B; CSVP; NISBD; TACE;
Species Homo sapiens
Ensembl Gene ENSG00000151694
Encoded Proteins
ADAM metallopeptidase domain 17
ADAM metallopeptidase domain 17
ADAM metallopeptidase domain 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:9488486-9555792
Strand Reverse strand
Band p25.1
Transcripts
ENST00000310823 ENSP00000309968
ENST00000497134 ENSP00000418728
ENST00000478059
ENST00000618923 ENSP00000480552
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002446 neutrophil mediated immunity
GO:0002467 germinal center formation
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0006915 apoptotic process
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008284 positive regulation of cell proliferation
GO:0010820 positive regulation of T cell chemotaxis
GO:0022617 extracellular matrix disassembly
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030574 collagen catabolic process
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032496 response to lipopolysaccharide
GO:0032717 negative regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493 response to drug
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048536 spleen development
GO:0048870 cell motility
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051272 positive regulation of cellular component movement
GO:0055099 response to high density lipoprotein particle stimulus
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0032587 ruffle membrane
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Notch pathway
EGFR1 pathway
REACTOME
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Signalling by NGF pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Extracellular matrix organization pathway
Extrinsic Pathway for Apoptosis pathway
Release of Hh-Np from the secreting cell pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by EGFR pathway
Cytokine Signaling in Immune system pathway
Signaling by ERBB4 pathway
Degradation of the extracellular matrix pathway
p75 NTR receptor-mediated signalling pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Apoptosis pathway
Signal Transduction pathway
Regulated proteolysis of p75NTR pathway
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Immune System pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Hedgehog ligand biogenesis pathway
TNF signaling pathway
Growth hormone receptor signaling pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Collagen degradation pathway
Nuclear signaling by ERBB4 pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Death Receptor Signalling pathway
KEGG
Notch signaling pathway pathway
Alzheimer's disease pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
Notch signaling pathway pathway
PID BIOCARTA
Proteolysis and signaling pathway of notch [Biocarta view]
Segmentation clock [Biocarta view]
G-secretase mediated erbb4 signaling pathway [Biocarta view]
PID NCI
ErbB4 signaling events
TNF receptor signaling pathway
p75(NTR)-mediated signaling
Cross-References
SwissProt P78536
TrEMBL B2RNB2 Q53RF5 Q53RS1 Q53S40
UniProt Splice Variant
Entrez Gene 6868
UniGene Hs.404914
RefSeq NM_003183
HUGO HGNC:195
OMIM 603639
CCDS CCDS1665
HPRD 04703
IMGT
EMBL AC073195 AC080162 AC092206 BC136783 CH471053 GQ402545 U69611 U69612 U86755 U92649
GenPept AAB51514 AAB51586 AAB53014 AAC39721 AAI36784 AAX93091 AAX93142 AAY14859 ACV30013 EAX00982
RNA Seq Atlas 6868