Version 5.4
Homo sapiens Gene: AP1M2
Summary
InnateDB Gene IDBG-27841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1M2
Gene Name adaptor-related protein complex 1, mu 2 subunit
Synonyms AP1-mu2; HSMU1B; MU-1B; MU1B; mu2
Species Homo sapiens
Ensembl Gene ENSG00000129354
Encoded Proteins
IDBP-27843
adaptor-related protein complex 1, mu 2 subunit
IDBP-764402
IDBP-762965
IDBP-765518
IDBP-760414
IDBP-763710
IDBP-764520
IDBP-760696
IDBP-765867
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. [provided by RefSeq, Jul 2008]
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10572671-10587315
Strand Reverse strand
Band p13.2
Transcripts
ENST00000250244 ENSP00000250244
ENST00000591676 ENSP00000466494
ENST00000592285 ENSP00000468260
ENST00000591240 ENSP00000465193
ENST00000590923 ENSP00000465685
ENST00000589571 ENSP00000467406
ENST00000589684 ENSP00000467498
ENST00000589348 ENSP00000465488
ENST00000587069 ENSP00000465865
ENST00000589809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006605 protein targeting
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006903 vesicle targeting
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003309
View Gene Order
ENSBTAG00000021160
Not yet available
Pathways
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7EL08
UniProt Splice Variant
Entrez Gene 10053
UniGene Hs.18894
RefSeq NM_001300887 NM_005498 XM_005259701
HUGO HGNC:558
OMIM 607309
CCDS CCDS45964
HPRD 06296
IMGT
EMBL AC011475
GenPept
RNA Seq Atlas 10053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca