Homo sapiens Gene: PDE8A
Summary
InnateDB Gene IDBG-27887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE8A
Gene Name phosphodiesterase 8A
Synonyms HsT19550;
Species Homo sapiens
Ensembl Gene ENSG00000073417
Encoded Proteins
phosphodiesterase 8A
phosphodiesterase 8A
phosphodiesterase 8A
phosphodiesterase 8A
phosphodiesterase 8A
phosphodiesterase 8A
phosphodiesterase 8A
phosphodiesterase 8A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:84980440-85139145
Strand Forward strand
Band q25.3
Transcripts
ENST00000310298 ENSP00000311453
ENST00000339708 ENSP00000340679
ENST00000394553 ENSP00000378056
ENST00000478717 ENSP00000432309
ENST00000485596 ENSP00000431976
ENST00000557957 ENSP00000453808
ENST00000559742 ENSP00000452907
ENST00000559086 ENSP00000454094
ENST00000560789
ENST00000557819
ENST00000558543
ENST00000557954
ENST00000561105
ENST00000561374
ENST00000560333
ENST00000561024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000156 two-component response regulator activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871 signal transducer activity
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006198 cAMP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0009187 cyclic nucleotide metabolic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.9333
RefSeq NM_001243137 NM_002605 NM_173454 XM_005254933
HUGO
OMIM
CCDS CCDS10336 CCDS10337 CCDS58397
HPRD 09114
IMGT
EMBL
GenPept
RNA Seq Atlas