Homo sapiens Gene: WDFY3
Summary
InnateDB Gene IDBG-27961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDFY3
Gene Name WD repeat and FYVE domain containing 3
Synonyms ALFY; ZFYVE25;
Species Homo sapiens
Ensembl Gene ENSG00000163625
Encoded Proteins
WD repeat and FYVE domain containing 3
WD repeat and FYVE domain containing 3
WD repeat and FYVE domain containing 3
WD repeat and FYVE domain containing 3
WD repeat and FYVE domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:84669610-84966391
Strand Reverse strand
Band q21.23
Transcripts
ENST00000295888 ENSP00000295888
ENST00000425179
ENST00000426414
ENST00000514711 ENSP00000424987
ENST00000504839
ENST00000509825
ENST00000505923
ENST00000512267
ENST00000514071 ENSP00000426813
ENST00000504990
ENST00000509172 ENSP00000425699
ENST00000502713 ENSP00000422741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0016239 positive regulation of macroautophagy
GO:0035973 aggrephagy
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0016234 inclusion body
GO:0016605 PML body
GO:0019898 extrinsic component of membrane
GO:0034274 Atg12-Atg5-Atg16 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL D6RJE4
UniProt Splice Variant
Entrez Gene 23001
UniGene Hs.480116 Hs.726339
RefSeq NM_014991 XM_005262858 XM_006714151 XM_006714152
HUGO HGNC:20751
OMIM
CCDS CCDS3609
HPRD 10304
IMGT
EMBL AC095046 AC104082 AC108021 AC110806
GenPept
RNA Seq Atlas 23001