Version 5.4
Homo sapiens Gene: WDFY3
Summary
InnateDB Gene IDBG-27961.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDFY3
Gene Name WD repeat and FYVE domain containing 3
Synonyms ALFY; ZFYVE25
Species Homo sapiens
Ensembl Gene ENSG00000163625
Encoded Proteins
IDBP-27963
WD repeat and FYVE domain containing 3
IDBP-477874
WD repeat and FYVE domain containing 3
IDBP-483184
WD repeat and FYVE domain containing 3
IDBP-484987
WD repeat and FYVE domain containing 3
IDBP-481782
WD repeat and FYVE domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:84669610-84966391
Strand Reverse strand
Band q21.23
Transcripts
ENST00000295888 ENSP00000295888
ENST00000425179
ENST00000426414
ENST00000514711 ENSP00000424987
ENST00000504839
ENST00000509825
ENST00000505923
ENST00000512267
ENST00000514071 ENSP00000426813
ENST00000504990
ENST00000509172 ENSP00000425699
ENST00000502713 ENSP00000422741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0016239 positive regulation of macroautophagy
GO:0035973 aggrephagy
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0016234 inclusion body
GO:0016605 PML body
GO:0019898 extrinsic component of membrane
GO:0034274 Atg12-Atg5-Atg16 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043940
View Gene Order
ENSBTAG00000013495
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.480116 Hs.726339
RefSeq NM_014991 XM_005262858 XM_006714151 XM_006714152
HUGO
OMIM
CCDS CCDS3609
HPRD 10304
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca