Version 5.4
Bos taurus Gene: WDFY3
Summary
InnateDB Gene IDBG-643259.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDFY3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013495
Encoded Proteins
IDBP-695817
WD repeat and FYVE domain containing 3
IDBP-695818
WD repeat and FYVE domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163625:
This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:101289985-101484302
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061443 ENSBTAP00000053365
ENSBTAT00000017949 ENSBTAP00000017949
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0016239 positive regulation of macroautophagy
GO:0035973 aggrephagy
Cellular Component
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0016234 inclusion body
GO:0016605 PML body
GO:0019898 extrinsic component of membrane
GO:0034274 Atg12-Atg5-Atg16 complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163625
View Gene Order
ENSMUSG00000043940
View Gene Order
Cross-References
SwissProt
TrEMBL F1N6Q9
UniProt Splice Variant
Entrez Gene 537096
UniGene Bt.105149
RefSeq XM_005198671 XM_005200274 XM_002707826 XM_617252
HUGO HGNC:20751
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018311 DAAA02018312
GenPept
RNA Seq Atlas 101909146 537096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca