Homo sapiens Gene: PER1
Summary
InnateDB Gene IDBG-27996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PER1
Gene Name period homolog 1 (Drosophila)
Synonyms hPER; PER; RIGUI;
Species Homo sapiens
Ensembl Gene ENSG00000179094
Encoded Proteins
period homolog 1 (Drosophila)
period homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jul 2008]
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8140472-8156506
Strand Reverse strand
Band p13.1
Transcripts
ENST00000354903 ENSP00000346979
ENST00000317276 ENSP00000314420
ENST00000582719 ENSP00000463054
ENST00000578089
ENST00000585284
ENST00000577424
ENST00000579098
ENST00000585095
ENST00000578223
ENST00000577253 ENSP00000462546
ENST00000583677
ENST00000584202 ENSP00000463661
ENST00000579065
ENST00000581395 ENSP00000464696
ENST00000583559 ENSP00000463369
ENST00000581082 ENSP00000462064
ENST00000579203
ENST00000581703 ENSP00000463385
ENST00000578950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000989 transcription factor binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019900 kinase binding
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002028 regulation of sodium ion transport
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0009416 response to light stimulus
GO:0009649 entrainment of circadian clock
GO:0010608 posttranscriptional regulation of gene expression
GO:0032922 circadian regulation of gene expression
GO:0042634 regulation of hair cycle
GO:0042752 regulation of circadian rhythm
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043153 entrainment of circadian clock by photoperiod
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046329 negative regulation of JNK cascade
GO:0070932 histone H3 deacetylation
GO:0097167 circadian regulation of translation
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900744 regulation of p38MAPK cascade
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Circadian Clock pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
Circadian rhythm pathway
INOH
PID BIOCARTA
PID NCI
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445534
RefSeq NM_002616 XM_005256689
HUGO
OMIM
CCDS CCDS11131
HPRD 03774
IMGT
EMBL
GenPept
RNA Seq Atlas