Homo sapiens Gene: DLX6
Summary
InnateDB Gene IDBG-28053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLX6
Gene Name distal-less homeobox 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000006377
Encoded Proteins
distal-less homeobox 6
distal-less homeobox 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:97005548-97011039
Strand Forward strand
Band q21.3
Transcripts
ENST00000518156 ENSP00000428480
ENST00000493273
ENST00000555308 ENSP00000451635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001501 skeletal system development
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0030326 embryonic limb morphogenesis
GO:0030855 epithelial cell differentiation
GO:0042472 inner ear morphogenesis
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060021 palate development
GO:0060322 head development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt P56179
TrEMBL G3V471
UniProt Splice Variant
Entrez Gene 1750
UniGene Hs.249196 Hs.648834
RefSeq NM_005222
HUGO HGNC:2919
OMIM 600030
CCDS CCDS47647
HPRD
IMGT
EMBL AC004774 AK094086 BC069363 BC103688 BC103689 BC103690 BC109381 CH236949 CH471091
GenPept AAC17832 AAH69363 AAI03689 AAI03690 AAI03691 AAI09382 BAG52812 EAL24122 EAW76744
RNA Seq Atlas 1750