Version 5.4
Homo sapiens Gene: SLC7A7
Summary
InnateDB Gene IDBG-2809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A7
Gene Name solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Synonyms LAT3; LPI; MOP-2; y+LAT-1; Y+LAT1
Species Homo sapiens
Ensembl Gene ENSG00000155465
Encoded Proteins
IDBP-2811
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-235121
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-235123
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-235125
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-482434
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-602468
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-593304
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-600667
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-584255
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-592075
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-603540
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-596852
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-584772
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-600702
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-594422
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
IDBP-600105
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:22773222-22829820
Strand Reverse strand
Band q11.2
Transcripts
ENST00000285850 ENSP00000285850
ENST00000397532 ENSP00000380666
ENST00000397529 ENSP00000380663
ENST00000397528 ENSP00000380662
ENST00000488800 ENSP00000421554
ENST00000555702 ENSP00000451881
ENST00000556287 ENSP00000450715
ENST00000554061
ENST00000555678
ENST00000554517 ENSP00000452083
ENST00000556350 ENSP00000451026
ENST00000554758 ENSP00000450671
ENST00000555251 ENSP00000451983
ENST00000557629 ENSP00000450495
ENST00000555911 ENSP00000452551
ENST00000557129 ENSP00000450729
ENST00000554741 ENSP00000451063
ENST00000555959 ENSP00000452256
ENST00000553874
ENST00000553351
ENST00000553632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006461 protein complex assembly
GO:0006520 cellular amino acid metabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000958
View Gene Order
ENSBTAG00000014821
Not yet available
Pathways
NETPATH
REACTOME
REACT_12560
Basigin interactions pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RFE5 G3V273 G3V2H8 G3V2L0 G3V362 G3V4U1 G3V5A1 G3V5W2
UniProt Splice Variant
Entrez Gene 9056
UniGene Hs.513147
RefSeq NM_001126105 NM_001126106 XM_006720302
HUGO HGNC:11065
OMIM 603593
CCDS CCDS9574
HPRD 04667
IMGT
EMBL AL135998
GenPept
RNA Seq Atlas 9056

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca