Homo sapiens Gene: SLC7A7
Summary
InnateDB Gene IDBG-2809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A7
Gene Name solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Synonyms LAT3; LPI; MOP-2; y+LAT-1; Y+LAT1;
Species Homo sapiens
Ensembl Gene ENSG00000155465
Encoded Proteins
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:22773222-22829820
Strand Reverse strand
Band q11.2
Transcripts
ENST00000285850 ENSP00000285850
ENST00000397532 ENSP00000380666
ENST00000397529 ENSP00000380663
ENST00000397528 ENSP00000380662
ENST00000488800 ENSP00000421554
ENST00000555702 ENSP00000451881
ENST00000556287 ENSP00000450715
ENST00000554061
ENST00000555678
ENST00000554517 ENSP00000452083
ENST00000556350 ENSP00000451026
ENST00000554758 ENSP00000450671
ENST00000555251 ENSP00000451983
ENST00000557629 ENSP00000450495
ENST00000555911 ENSP00000452551
ENST00000557129 ENSP00000450729
ENST00000554741 ENSP00000451063
ENST00000555959 ENSP00000452256
ENST00000553874
ENST00000553351
ENST00000553632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006461 protein complex assembly
GO:0006520 cellular amino acid metabolic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Amino acid transport across the plasma membrane pathway
Basigin interactions pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513147
RefSeq NM_001126105 NM_001126106 XM_006720302
HUGO
OMIM
CCDS CCDS9574
HPRD 04667
IMGT
EMBL
GenPept
RNA Seq Atlas